Paradoxical sleep deprivation increases plasma endothelin levels
The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities.ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA).